Vashan Compounding Pharmacy specializes in compounding pure LDN capsules from 1–6mg. A proven non-opioid alternative for chronic pain, autoimmune conditions, and weight management.
Low Dose Naltrexone, also known as LDN, has become one of the most promising non-opioid therapies for chronic pain, autoimmune conditions, and inflammatory disease. At Vashan Compounding Pharmacy in Gaithersburg, Maryland, we specialize in compounding pure LDN capsules in precise doses that are not commercially available — making us one of the most experienced LDN compounding pharmacies in the region.
Naltrexone is an FDA-approved opiate receptor antagonist originally developed for opioid and alcohol use disorders. At standard doses (50mg), it fully blocks opioid receptors for an extended period. At low doses (1–6mg), however, it briefly blocks these receptors for just a few hours — triggering the body to produce significantly more endorphins and upregulate immune function.
This short-term receptor blockade at low doses creates a cascade of beneficial effects: reduced neuroinflammation, improved immune regulation, and enhanced pain tolerance — without the side effects or addiction risks of opioid medications.
Clinical and anecdotal evidence supports LDN as a therapeutic option for a wide range of conditions. Practitioners across the country are prescribing LDN for patients who have not responded well to conventional treatments.
LDN has shown significant promise in reducing pain and fatigue in fibromyalgia patients. A Stanford University pilot study found that patients taking LDN reported a 30% reduction in pain compared to placebo, with improvements in mood and quality of life.
Multiple clinical trials have demonstrated LDN's ability to induce and maintain remission in Crohn's disease and inflammatory bowel conditions. Its anti-inflammatory effect on the gut lining makes it particularly valuable for patients who cannot tolerate standard biologic therapies.
LDN is widely used among MS patients for reducing fatigue, improving quality of life, and slowing disease progression. It is one of the most commonly requested off-label therapies among the MS community.
By modulating microglial cell activity and reducing pro-inflammatory cytokines, LDN may help patients with rheumatoid arthritis, lupus, psoriasis, Hashimoto's thyroiditis, and other autoimmune disorders achieve better symptom control.
LDN acts as a glial cell modulator, reducing the neuroinflammation that drives many chronic pain conditions. It is increasingly prescribed as an adjunct or alternative to opioid therapy for conditions like CRPS, neuropathic pain, and central sensitization.
LDN supports weight loss through multiple mechanisms: appetite regulation via endorphin pathways, reduction of systemic inflammation, improvement in insulin sensitivity, enhancement of growth hormone response, and support of healthy thyroid function. It is often combined with other compounded weight management therapies.
Naltrexone is only commercially available as a 50mg tablet — far too high a dose for LDN therapy. The therapeutic range for LDN is 1–6mg, which means every LDN prescription must be compounded by a licensed compounding pharmacy.
At Vashan Compounding Pharmacy, we prepare LDN capsules using pharmaceutical-grade naltrexone sourced from FDA-registered facilities. We compound the following doses:
LDN capsules are typically taken 1–2 hours before bedtime (around 9:00 PM) for maximum efficacy, as endorphin production naturally peaks during early sleep hours.
LDN is well-tolerated by most patients. The most commonly reported side effect is vivid dreams (reported in approximately 37% of patients), which typically decreases over the first few weeks of therapy. In rare cases, mild headaches may occur, particularly when starting therapy — a slow titration protocol can help minimize this.
LDN does not cause dependency, withdrawal, or the serious side effects associated with opioid medications or many immunosuppressant drugs.
LDN requires a prescription from a licensed healthcare provider — a physician, nurse practitioner, or other qualified prescriber. Once you have a prescription, bring it to Vashan Compounding Pharmacy or have your provider send it directly to us.
Not sure if LDN is right for you? Our compounding pharmacists are happy to speak with you or your provider about whether LDN may be appropriate for your condition.
Yes. Low dose naltrexone is a prescription medication in the United States. Your doctor, nurse practitioner, or qualified prescriber must write a prescription for LDN before it can be compounded.
We compound LDN in doses ranging from 1mg to 6mg. The most commonly prescribed starting dose is 1.5mg, titrating up to 4.5mg over several weeks depending on patient response.
Yes. Vashan Compounding Pharmacy is located in Gaithersburg, MD (20877) and serves patients throughout Maryland, Northern Virginia, and the Washington DC metro area. We can also ship compounded LDN to patients across Maryland with a valid prescription.
Most patients begin to notice benefits within 4–8 weeks of consistent use. Some conditions, particularly autoimmune disorders, may require 3–6 months of therapy before full benefits are realized.
Because LDN is compounded and used off-label for most conditions, it is typically not covered by standard insurance. However, the cost of compounded LDN is generally quite affordable compared to branded biologics or long-term opioid therapy.
Contact Vashan Compounding Pharmacy at 301-947-4747 or email rx@vashan.com to send your LDN prescription or speak with our pharmacist.
our compounding professionals can prepare
tailored medication for your condition
multiple medication in a single dose
various formulation for easy application
not commercially avaiable medication